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BYU Transition Checklist

As part of the upcoming transition from iRIS to OneAegis, all investigators at Brigham Young University must take specific steps to ensure uninterrupted research operations and compliance with university and IRB requirements. All new IRB applications must now be submitted exclusively through OneAegis. The final day to secure IRB approval for submissions still in iRIS is October 24, 2025.

To support this transition, the Human Research Protection Program (HRPP) has developed a comprehensive checklist to guide you through the essential tasks that must be completed before iRIS is retired.

BYU Transition Checklist: iRIS to OneAegis

1. Download & Archive Study Documents

  • We strongly encourage you to download your studies just in case there is a problem during the transition process. Download the following documents:
    • IRB-approved protocols 
    • Consent forms 
    • Correspondence and approval letters 
  • Archive final versions of current documents in your local/shared drive 
  • You can access written instructions here and a training video here
2. Finalize In-Progress Submissions

  • iRIS is now closed for all new submissions
  • Monitor iRIS dashboards to confirm completion of all submissions before October 24, 2025.
  • Draft applications, responses, modifications and renewals will not be transferred to OneAegis. You should copy and paste the content into OneAegis
3. Review Study Statuses

  • Confirm the current status of all active studies in iRIS (Approved, Pending, etc.) 
  • Resolve any studies that are in “Pre-Submission” or “Returned for Changes” status 
  • Flag studies under continuing review and plan submission after October 24.  
4. Prepare for Transition to OneAegis

  • Click here to access OneAegis Training resources
5. Backup & Save Critical Communications

  • Save important messages from BYU IRB about your studies 
  • Export communication threads related to study approvals, reviews, or stipulations 

6. Communicate with Study Teams

  • Notify all co-investigators, coordinators, and staff of transition deadlines